Histopathological Analysis of Ovarian lesions in Erbil Maternity Hospital

Authors

  • Payman Anwar Rashid Department of Anatomy and Pathology, College of Medicine, Hawler Medical University and Department of Medical Analysis, Faculty of Applied Sciences, Tishk International University.

DOI:

https://doi.org/10.15218/crewh.2024.05

Keywords:

Ovarian cysts, Benign tumor, Malignant tumor, Histopathology.

Abstract

Background: The histopathological analysis of ovarian lesions is critical for accurate diagnosis and treatment planning. Despite advancements in imaging techniques, histopathology remains the gold standard for identifying specific cell types and distinguishing between benign and malignant ovarian lesions. This study aims to evaluate the histopathological characteristics of ovarian lesions at Erbil Maternity Hospital to enhance diagnostic accuracy and patient outcomes. Material & Method: This descriptive cross sectional study analyzed data from 318 patients who underwent surgery for ovarian cysts at Erbil Maternity Hospital for a period of three years. The data included patient age, type of operation, size, tumor location, and gross and microscopical findings. Descriptive statistics summarized the data, and statistical tests were used to identify correlations between variables. Result: The age of patients ranged from 14 to 62 years, with a mean age of 42 years. The most common operation was cystectomy (36.16%), followed by total abdominal hysterectomy and unilateral salpingo-oophorectomy (22.95%). Cysts were evenly distributed between the right and left ovaries, with (5.6%) being bilateral. Cyst sizes varied, with (25.47%) being less than 5 cm. Gross cut sections were diverse, with (63.83%) cystic. The most common non-neoplastic cyst was corpus luteal cysts (22.01%), while the most common benign tumor was mature cystic teratoma (20.12%). The malignant tumor was serous cystadenocarcinoma (1.57%). Conclusion:
Ovarian lesions are commonly encountered surgical specimens. They often present as a mass lesion so it is difficult to categorize them as non-neoplastic or neoplastic based on clinical, radiological or surgical findings. Histopathological examination is needed to diagnose these lesions and to categorize them for proper treatment.

References

- Hadadi, N, S., Ayatollahi, H. and Noushyar, M. (2023) "Evaluation of the Expression Intensity of Glucose Transporter-1 Marker and its Diagnostic Value in Differentiating Between Borderline and Malignant Ovarian Epithelial Tumors," Disease and diagnosis, 12(2),p. 63-69. Available at: https://doi.org/10.34172/ddj.2023.441.

- Gafur, A. et al. (2018) "Serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) level difference in benign and malignant epithelial ovarian tumor," Bali Medical Journal, 7(1),p. 132-132. Available at: https://doi.org/10.15562/bmj.v7i1.809.

- Afrin, W. et al. (2023) "Comparison between Clinical and Laparotomy Findings of Ovarian Tumou," Scholars journal of applied medical sciences, 11(07),p. 1331-1337. Available at: https://doi.org/10.36347/sjams.2023.v11i07.022.

- Yalaza, C. et al. (2023) "Role of acetyl-CoA acetyltransferase 1 expression in the molecular mechanism of adenomyosis," Türk jinekoloji ve obstetrik derneği dergisi, 20(3),p. 174-178. Available at: https://doi.org/10.4274/tjod.galenos.2023.05942.

- Tischkowitz, M. et al. (2020) "Small-Cell Carcinoma of the Ovary, Hypercalcemic Type–Genetics, New Treatment Targets, and Current Management Guidelines," Clinical Cancer Research, 26(15),p. 3908-3917. Available at: https://doi.org/10.1158/1078-0432.ccr-19-3797.

- Zahrani, A, R. (2023) "Histological changes in the background renal parenchyma in neoplastic nephrectomies and nephroureterectomy: A 10-year single-center experience," Journal of Microscopy and Ultrastructure, 11(2),p. 103-103. Available at: https://doi.org/10.4103/jmau.jmau_87_21.

- Mouhamed, A, H. and Mouhamed, A, H. (2017) The Diagnostic Utility of Immunohistochemistry in Undifferentiated OvarianCarcinoma. Available at: https://www.acanceresearch.com/cancer-research/the-diagnostic-utility-of-immunohistochemistry-in-undifferentiated-ovariancarcinoma.php?aid=19621.

- Luh, N, P, C, L. et al. (2019) "Management Comprehensive Multidisciplinary of Malignant Ovarian Germ Cell Tumors and Feto - Maternal Outcome: A Case Series Report and Literature Review," Open Access Macedonian Journal of Medical Sciences, 7(7),p. 1174-1179. Available at: https://doi.org/10.3889/oamjms.2019.251.

- Zeinali-Rafsanjani, B., Zarei, F. and Khatamizadeh, N. (2023) "Assessment of the adherence of radiologists in reporting the ovarian cysts to the 2010 society of radiologists in ultrasound guidelines," Journal of Medical Ultrasound, 31(2),p. 107-107. Available at: https://doi.org/10.4103/jmu.jmu_137_21.

- He, Y. et al. (2020) "Development and Validation of an RNA-Binding Protein-Based Prognostic Model for Ovarian Serous Cystadenocarcinoma," Frontiers in Genetics, 11. Available at: https://doi.org/10.3389/fgene.2020.584624.

- The Diagnostic Utility of Immunohistochemistry in Undifferentiated OvarianCarcinoma (2017). Available at: https://www.acanceresearch.com/cancer-research/the-diagnostic-utility-of-immunohistochemistry-in-undifferentiated-ovariancarcinoma.php?aid=19621.

- Baru, L., Patnaik, R. and Singh, B, K. (2017) "Clinico pathological study of ovarian neoplasms," International journal of reproduction, contraception, obstetrics and gynecology, 6(8),p. 3438-3438. Available at: https://doi.org/10.18203/2320-1770.ijrcog20173459.

- Zhang, Y., Wang, X. and Chen, X. (2021) "Identification of core genes for early diagnosis and the EMT modulation of ovarian serous cancer by bioinformatics perspective," Aging, 13(2),p. 3112-3145. Available at: https://doi.org/10.18632/aging.202524.

- Yadav, G. et al. (2020) "Molecular biomarkers for early detection and prevention of ovarian cancer—A gateway for good prognosis: A narrative review," International Journal of Preventive Medicine, 11(1),p. 135-135. Available at: https://doi.org/10.4103/ijpvm.ijpvm_75_19.

- Moyle, W. R., S. J. Campbell, M. M. Wang, et al. (2005). "Clinical Characteristics and Diagnostic Evaluation of Women with Ovarian Cysts." Obstetrics & Gynecology 105(1): 57-64.

- Modesitt, S. C., Pavlik, E. J., Ueland, F. R., et al. (2003). "Risk of malignancy in unilocular ovarian cystic tumors less than 10 centimeters in diameter." Obstetrics & Gynecology 102(3): 594-599.

- Shih, I. M., & Kurman, R. J. (2002). "Ovarian tumorigenesis: a proposed model based on morphological and molecular genetic analysis." The American Journal of Pathology 161(3): 592-597.

- Alcázar, J. L., Pascual, M. A., Olartecoechea, B., et al. (2008). "Differentiation between benign and malignant adnexal masses: Prospective validation of the IOTA logistic regression models." Gynecologic Oncology 110(2): 252-256.

- Levine, D., Brown, D. L., Andreotti, R. F., et al. (2010). "Management of asymptomatic ovarian and other adnexal cysts imaged at US Society of Radiologists in Ultrasound consensus conference statement." Radiology 256(3): 943-954.

- Kurman, R. J., Carcangiu, M. L., Herrington, C. S., & Young, R. H. (Eds.). (2011). WHO Classification of Tumours of Female Reproductive Organs. Lyon: IARC Press.

- Russell, P., Robboy, S. J., Anderson, M. C. (2002). Russell and Rubinstein's Pathology of Tumors of the Female Genital Tract. 6th ed. Churchill Livingstone.

- Bell, D., Berchuck, A., Birrer, M., et al. (2011). "Integrated genomic analyses of ovarian carcinoma." Nature 474(7353): 609-615.

- Young, R. H., & Clement, P. B. (2006). "Pathology of the Ovary, Fallopian Tube, and Peritoneum." Contemporary Issues in Surgical Pathology. New York: Churchill Livingstone.

- Seidman, J. D., Yemelyanova, A., Cosin, J. A., et al. (2006). "The distribution of invasive carcinoma in advanced stage ovarian serous carcinoma." Gynecologic Oncology 103(2): 703-706.

- Bast, R. C., Hennessy, B., & Mills, G. B. (2009). "The biology of ovarian cancer: new opportunities for translation." Nature Reviews Cancer 9(6): 415-428.

- Cannistra, S. A. (2004). "Cancer of the ovary." The New England Journal of Medicine 351(24): 2519-2529.

Downloads

Published

2025-06-01

How to Cite

Rashid, P. A. (2025). Histopathological Analysis of Ovarian lesions in Erbil Maternity Hospital. HMU Conference Proceedings, (4), 66–74. https://doi.org/10.15218/crewh.2024.05

Issue

Section

Proceeding